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Generex Biotechnology, and their wholly owned subsidiary Antigen Express, are developing promising new drugs to treat diabetes, as well as synthetic peptide vaccines targeting HER2/neu cancer and pandemic flu. The flagship product for Generex is Oral-lyn buccal insulin. Antigen Express' leading vaccine is the AE37 HER2/neu synthetic peptide vaccine to prevent breast cancer recurrence. I am not qualified to offer investment or medical advice, and make no claims that I am an expert in these areas. I am a layman and a shareholder in this company. The left side of Pipeline Review holds blogs regarding Generex and Antigen Express, while the right side offers items of due diligence mixed with my analysis which may be of interest to others seeking to learn about Generex's pipeline. If the left side only shows the latest blog, click on the word home to view them all.

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Tuesday, March 23, 2010

Diabetics may be able to skip the shots thanks to a spray

Copyright 2010 / Article from Medstar:

No one likes shots. However, if you're an insulin-dependant diabetic, those injections are a requirement. But there is a new way to deliver insulin, one spritz at a time.

If you didn't know better, you'd think Steven Elkman has asthma.

"And nobody really notices because so many people use inhalators for asthmatic medications, that, you know, it doesn't really attract any attention," said Steven.

But Steven's actually managing Type 2 diabetes with a unique insulin delivery system.

"It's literally a spray that goes into your mouth, and the spray actually is in, in a form so that about one unit per spray of insulin can get absorbed into your body," Dr. Dennis Gage, an endocrinologist at Beth Israel Medical Center in New York City.

The experimental spray, called Oral-lyn, may offer an option for patients who fear injections.

"You know the ‘insulin' word, and they get nervous and they just would rather not go there and that, that's a frequent problem," Dr. Gage said.

In this case, the insulin is packaged in a spray bottle, and is spritzed in the mouth just before meals.

"Depending on how much they're on, they may need five sprays, six sprays, ten sprays," said Dr. Gage. "But we build that up based on their blood sugar ‘til it's really perfect."

The insulin is absorbed through mouth tissue and enters the bloodstream from there. If Oral-lyn gets FDA approval, the spray may be the only medication some Type 2 diabetics will need.

"We're trying to remove one oral medication at a time, and ideally then I would just be on this," said Steven.

An injection-free device that may revolutionize the way insulin gets into the body.

link is here.